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The Gut-Heart Axis: The Role of the Microbiome in Coronary Heart Disease

Ever wondered if following your gut instinct and listening to your heart could go hand in hand? Apparently, the answer is - yes! Trillions of bacteria from hundreds of species inhabit our gut. You might sometimes have an imbalance in the gut microbiome – too many harmful bacteria and not enough good bacteria (dysbiosis). In such a situation, the gut microbiome may interfere with the tranquillity of our hearts. Gut microbiota has a causal relationship with coronary heart disease (CHD). CHD is a chronic disease that interferes with blood transportation from the arteries to the heart. Cholesterol accumulation causes plaque formation, which can narrow blood vessels, causing reduced blood supply. Cholesterol can even block arteries. 

The bacteria in our gut produce trimethylamine, SCFAs (short-chain fatty acids), and bile acids from food. If the gut barrier is leaky due to dysbiosis, these metabolites can contribute to the development of coronary heart disease. Also, dysbiosis is associated with risk factors for CHD, including diabetes, dyslipidaemia, and hypertension.  

So, how are these minuscule creatures in the gut potentially associated with CHD? The answer is that the gut microbiota intervenes in various metabolic processes, including cholesterol and uric acid metabolism, inflammatory events, and oxidative stress through the metabolites the bacteria make. Any dysregulation in the gut microbiome may lead to the development of CHD. Recent research has shown that probiotics have the potential to ease CHD. Probiotic supplements can modulate the composition of gut bacteria, thereby relieving dysbiosis. Thus, probiotics are emerging as part of the arsenal for treating CHD, and Genofax™ is developing scientific tools that provide recommendations for Personalised Probiotics™ with known benefits.  

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